He closed his eyes and visualized his own brain. In his mind's eye, he saw the hippocampus, the part of the brain responsible for memory and emotion. In cases of prolonged stress and depression, high levels of a hormone called cortisol can actually damage this area, causing it to shrink. He realized that the constant academic stress and isolation he had put himself through had likely triggered this toxic flood.
This realization was the spark he needed. He couldn't just "think" himself out of a chemical imbalance, but he could use science to rebuild his brain's chemistry. He knew about neuroplasticity—the brain’s incredible ability to reorganize itself by forming new neural connections throughout life.
He knew the textbook answer. Depression was not a choice, nor was it simply "being sad." It was a complex biological storm.
For months, he had ignored the signs. He blamed his chronic fatigue on long hours at the lab. He dismissed his sudden lack of interest in playing the guitar—something he used to love—as just "getting older." But today, staring at the blank white ceiling, the scientist in him began to analyze his own despair. "What is happening to me?" he whispered to the empty room.