The main campaign takes place at least a year after the initial zombie outbreak. Civilization has collapsed, and a new threat called the has emerged.

If you want a more traditional, linear story, the game includes:

In , there isn't just one fixed story; instead, the game is a "survival fantasy" sandbox where you create your own narrative through the survivors you recruit and the choices you make. However, there are established lore elements and specific story-driven modes you can follow. The Core Story: Surviving the Plague