The phrase "The Juice is Loose" refers to O.J. Simpson's nickname ("The Juice") and his status following his high-profile acquittal in the 1990s.
After a misunderstanding, Peter becomes convinced of O.J.'s innocence and invites him to stay with the Griffins in Quahog. [S7E9] The Juice Is Loose
The residents of Quahog are hostile toward their new neighbor, leading to a confrontation that forces O.J. to eventually reveal his true nature. Key Character Guide The phrase "The Juice is Loose" refers to O
Voiced by Mike Henry, he is portrayed as a misunderstood figure who eventually reveals a darker side. [S7E9] The Juice Is Loose