: Christian McCaffrey dominated with 129 rushing yards and two touchdowns .
: The teams have split two postseason meetings ( 1–1 ). NFL San Francisco 49ers Vs Atlanta Falcons
The San Francisco 49ers and Atlanta Falcons share a deep-rooted history, having met since 1966 . Once fierce division rivals in the NFC West , they now face off as cross-divisional foes after the Falcons moved to the NFC South in 2002. Mon, Oct 20 49ers won! Recent Matchup (October 19, 2025) : Christian McCaffrey dominated with 129 rushing yards