: The primary regulator of insulin-dependent glucose uptake in muscle and adipose tissue.
: Predominantly expressed in the brain, where it regulates organ size and neurodevelopment. 3. Pathological Dysregulation 3.1 Cancer File: AKT_collection_compressed_2022-11-20.zip ...
Multi-Isoform AKT Signaling: A Systems-Level Analysis of Cellular Homeostasis and Oncogenesis : The primary regulator of insulin-dependent glucose uptake
Research indicates that AKT isoforms are not functionally redundant: alter the PH domain structure
Somatic mutations in AKT, particularly the , alter the PH domain structure, leading to constitutive membrane localization and hyperactivation of downstream effectors like mTOR and ERK1/2. This promotes uncontrolled proliferation and resistance to apoptosis. AKT1 Transcriptomic Landscape in Breast Cancer Cells - MDPI