Aspirin -

Unlike other NSAIDs like ibuprofen, aspirin permanently disables the COX enzyme for the life of the platelet (about 8–10 days).

While generally safe, aspirin carries risks, particularly when used long-term: aspirin

It is generally recommended not to give aspirin to children under 16 due to the risk of Reye's syndrome, a rare but serious condition. Unlike other NSAIDs like ibuprofen